Reversible inhibitor

For acetylcholine esterase (AChE), reversible inhibitors are those that do not irreversibly bond to and decactivate AChE.[1]

Drugs that reversibly inhibit acetylcholine esterase are currently being explored as treatments for Alzheimer's disease and myasthenia gravis, among others. Examples include tacrine and aricept.[2]

See also

References

  1. ^ Millary, CB; Kryger, G (199). "Crystal structures of aged phosphorylated acetylcholinesterase: nerve agent reaction products at the atomic level". Biochemistry (Weizmann Institute of Science) 38 (22): 7032–7039. doi:10.1021/bi982678l. PMID 10353814. 
  2. ^ Julien, Robert. A Primer of Drug Action (Eleventh ed.). Worth Publishers. pp. 50. ISBN 9781429206792.